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Omeprazole ODT is a PPI, otherwise known as a 'proton-pump inhibitor.' PPIs prevent heartburn by deactivating many of the pumps in the stomach lining that produce acid. PPIs are available over the counter for frequent heartburn sufferers and provide 24 hour relief. Although some people experience relief in the first 24 hours, it may take 1-4 days to begin working.

H2 Blockers

H2 blockers partially block production of acid in the stomach cells by inhibiting histamine, a substance that stimulates secretion of stomach acid. These acid reducers prevent and relieve heartburn associated with acid indigestion and sour stomach when taken 30-60 minutes before a meal.


Antacids create a basic chemical reaction that partially neutralizes stomach acid to provide short-term relief for heartburn more quickly than an H2 blocker or PPI. Antacids are best for occasional, relatively mild cases of heartburn that are caused by a specific event or behavior, such as overeating at a holiday dinner or eating spicy foods.

How To Know What To Take

Takes effect Duration Best for
PPI (Proton Pump Inhibitor) Within 1-4 days when taken as directed Long-term Frequent heartburn occurring two or more days a week
H2 Blocker Within 1 hour Short-term Occasional heartburn associated with acid indigestion or sour stomach. Can be used as a preventative measure when taken 1 hour before a meal
Antacid Quickly Short-term Occasional sour stomach, heartburn, and acid indigestion

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